A REVIEW OF PHARMACEUTICAL NANO-COCRYSTAL: A NOVEL STRATEGY TO IMPROVE THE CHEMICAL AND PHYSICAL PROPERTIES FOR POORLY WATER SOLUBLE DRUGS

Abstract

Drugs are a crucial commercial good in our lifestyle because they help us stay healthy and treat illnesses. Poor solubility,
permeability, bioavailability, dissolving rate, hygroscopicity, tablet ability, compressibility, and stability of medicines are
major causes of medication failure during clinical development. To overcome the shortcomings of pharmaceuticals,
several methods can be created including salt formation, Nano-formulations, co-solvency, complexation with
cyclodextrins and surfactants, micronization, solid dispersions, coamorphous formulations, cocrystallization,
nanococrystallization, etc.
Nanococrystallization is the approach that has the best chance of enhancing the physical and chemical characteristics of
APIs without altering their chemical composition. With the extra advantage of a carrier-free delivery route,
nanococrystallization offers a flexible technique for saving poorly soluble medicines. In this review, we provide a
comprehensive analysis of nanococrystals. In these we also compare the cocrystal with nano cocrystal along with the
formulation methods, advantages and characterization techniques for nanococrystals.