INHIBITION OF LIPOXYGENASE BY ELEPHANTOPUS SCABER EXTRACT AND DETERMINATION OF ITS INHIBITION PATTERN

Abstract

Elephantopus scaber Linn, a medicinal herb indigenous to India, has been widely used in treating a number of inflammatory pathological conditions. In the present study, methanolic extract of E. scaber was evaluated for its ability to inhibit 5, 12 and 15 Lipoxygenase enzymes (LO) and the nature of inhibition was determined from Km and Vmax values obtained from Lineweaver Burk plot. The methanolic extract was found to inhibit all three LO enzymes in a mixed competitive non competitive nature. E. scaber promises to be a good source of bioactive molecules that could be employed for inflammation research.