A PROSPECTIVE OBSERVATIONAL STUDY ON PRESCRIBING PATTERN IN LIVER TRANSPLANT RECIPIENTS

Abstract

The liver transplant is a surgical procedure in which the diseased liver of recipient is replaced with the healthy liver of donor. Our research involved 70 patients who underwent liver transplant and it was single centered. This study’s objective was to evaluate the medications used in liver transplantation. In our study we found that most common cause for liver transplantation is cryptogenic and second most cause is alcoholic related.

Immunosuppressants and prophylaxis antimicrobials were primarily prescribed. In immunosuppressants, triple drug regimen was given for 74.28% and Quadruple regimen was prescribed for 18.5%. TDM immunosuppressants were performed during hospital stay. Meropenem is the major antibiotic used as prophylactic therapy, Valganciclovir is regularly prescribed antiviral whereas Fluconazole is usually prescribed antifungal. Immunosuppressants: 74.28% patients were prescribed with tacrolimus + mycophenolate mofetil + prednisolone (Triple therapy); Tacrolimus + Mycophenolate mofetil + prednisolone + Everolimus/Cyclosporine (18.5%). Antibiotics: 78.57% of patients were prescribed with Meropenem. Antiviral: 88.57% of patients were prescribed with Valganciclovir. Antifungal: 94.28% of patients were prescribed with Fluconazole. The length of hospital stay for many patients was 16-20 days.