Mechanistic Synthesis of 1-Pyridylimidazo [1, 5-a] Pyridines by Using K4 [Fe (CN)6] .3H2O

Abstract

Potassium Ferro-Cyanide complex catalyzed three component improved procedure for the synthesis of various 1-pyridylimidazo [1, 5-a] pyridines from 1, 2-dipyridyl ketone, aromatic aldehydes and ammonium acetate at room temperature in excellent isolated yield has been reported. This is a simple and straight forward, high yielding, does not involve any hazardous or expensive catalyst. The synthesis is purely solvent free (Mechanostic).