EVALUATION OF ACUTE TOXICITY EFFECT OF SMILAX GLABRA EXTRACT ON WHITE ALBINO RATS

Abstract

Smilax Glabra is a Chinese Medicinal plant used for the treatment of the many diseases. The purpose of the study was to test the acute oral toxicity of the extract of the plant rhizome. Acute toxicity of aqueous extract of Smilax glabra was evaluated in albino Swiss female mice. The acute toxicity studies were carried out based on OECD guidelines and 423 and fixed dosage studies was adopted where the limit dose is 3gm/kg body weight of test animal. Were orally administered a single dose of 3gm, 5gm/kg body weight. Sign of toxicity and mortality were noted after 24 hrs.of administrations (5gm/kg body weight) did not produced mortality or changes in the general behavior of the test animals. These results indicates that the safety usage of extract from this plant in traditional medicine.