Structural and Biological Studies of Newly Synthesized Co(II) Coordination Complexes with Hydrazine Hydrate-based Azomethine Ligands

Abstract

This research work reports the synthesis of novel biologically active cobalt-Azomethine coordination complexes [Co(L_n)₂Cl₂]. The Azomethine ligands have been synthesized by the condensation of hydrazine hydrate with aldehydes and ketones, which was then used to synthesize novel Co(II)-Azomethine coordination complexes and isolated as solid powdered product. The Azomethine ligands and their biologically active Co(II)-Azomethine coordination complexes [Co(L_n)₂Cl₂] were characterized for the molecular weight determination, elemental analysis, ¹H NMR and FT-IR spectroscopy. The Azomethine ligands and their Co(II)-Azomethine coordination complexes [Co(L_n)₂Cl₂] has also been characterized for the antimicrobial activity against several bacterial and fungal species, which has been associated with the standard bactericide Ciprofloxacin and fungicide Ketoconazole. The outcome of the research has indicated that Co(II)-Azomethine coordination complexes [Co(L_n)₂Cl₂] were found to retain excess antimicrobial activity against bacterial and fungal species as compared to the free azomethine ligands.