Development and Evaluation of Raft-Forming Rosiglitazone Maleate Tablets for Enhanced Drug Delivery

Abstract

This research aimed to enhance patient satisfaction by improving the absorption and effectiveness of Rosiglitazone Maleate. Floating tablets were developed using a raft-forming method. Compatibility assessments, including physical observation and FTIR analysis, confirmed minimal drug-polymer interaction. Nine formulations were prepared using varying ratios of HPMC K15M, Guar gum, Chitosan, sodium bicarbonate (effervescent agent), sodium alginate (viscous gel-forming agent), and MCC (diluent). The tablets were evaluated for weight variation (345.09 mg - 352.72 mg), hardness (< 5 kg/cm2), thickness (3.0 - 3.8 mm), friability, drug content uniformity, floating lag time, and in vitro drug release. All formulations exhibited favorable floating properties. Formulation F7 demonstrated 91.68% drug release over twelve hours. Sodium bicarbonate and sodium alginate primarily influenced buoyancy lag time, while HPMC K15M and Guar gum significantly affected drug release. These findings suggest that raft-forming Rosiglitazone Maleate tablets offer a promising approach to improve drug absorption, effectiveness, and patient satisfaction.