Phytochemical Composition and Antioxidant-Mediated Pharmacological Activities of Aegle marmelos (L.) Corr.: A Narrative Review

Abstract

Aegle marmelos (L.) Corr. is a medicinal plant extensively used in traditional systems for the management of gastrointestinal, metabolic, and inflammatory disorders. Increasing experimental evidence suggests that many of its pharmacological effects are mediated through antioxidant mechanisms. The present narrative review aims to critically summarize and evaluate published literature on the phytochemical composition and antioxidant-related pharmacological activities of Aegle marmelos. Relevant studies were retrieved from scientific databases including PubMed, Scopus, Google Scholar, and ScienceDirect using appropriate keywords. Experimental findings indicate that different parts of the plant, particularly leaves and fruits, possess significant antioxidant activity in various in vitro and in vivo models, largely attributed to the presence of phenolics, flavonoids, coumarins, and terpenoids. However, most studies rely on crude extracts and in vitro assays, with limited standardization and insufficient clinical validation. This review highlights existing research gaps and emphasizes the need for compound-level investigations, bioavailability studies, and well-designed clinical trials to support the therapeutic potential of A. marmelos in oxidative stress-related disorders.