Advanced Modes of Inductively Coupled Plasma - Mass Spectrometry (ICP-MS) for Reducing Spectral Interferences on Matrix Based in Food Matrices

Abstract

Inductively coupled plasma mass spectrometry (ICP-MS) is a highly sensitive analytical technique for determining trace and ultra-trace levels of elements in complex matrices such as food and beverages. Its accuracy can be compromised by spectral and non-spectral interferences arising from the sample matrix. This study explores the application of advanced ICP-MS operational modes, specifically, collision/reaction cell (CRC) technology using helium (He) and hydrogen (H₂) gases to reduce these interferences during the quantification of iron (Fe), arsenic (As), and selenium (Se) in packaged drinking water, representing a food-based matrix. During the analysis, potential spectral interferences such as ArCl⁺ on As-75, ArO⁺ on Fe-57, and Ar₂⁺ on Se-77 were effectively reduced using advanced ICP-MS modes, specifically CRC technology. By introducing helium (He) or hydrogen (H₂) gases into the cell, these interfering polyatomic ions are dissociated or neutralized before detection, allowing accurate and interference-free measurement. The study demonstrates that advanced interference-removal modes in ICP-MS play a crucial role in achieving precise and reliable quantification of trace elements in complex matrices such as food and beverages. The techniques provide high sensitivity, selectivity, and accuracy, making ICP-MS an indispensable tool for ensuring food and water safety in compliance with global quality standards.