FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF PARACETAMOL

Abstract

Fast dissolving tablets (FDTs) are novel types of tablets that disintegrate or disperse in saliva within few seconds without water. Paracetamol was used as a model drug in this formulation. Paracetamol is widely prescribed antipyretic and analgesic drug for all age groups. All the formulations were prepared using direct compression method, which is a conventional method of preparation. Various parameters like pre 8 post-compressional parameters were tested and final formula was selected based on in-vitro dispersion time and in-vitro dissolution profile. Where, all the formulations were dispersed less than 40 seconds and F6 formulation was showing 100% release at 25 minute and faster, compared to the marketed formulation and the formulation was found to be stable.