Effect of Various Super Disintegrants on Hardness, Disintegration and Dissolution of Drug from Dosage Form

Abstract

In this study the effect of various disintegrants on the disintegration time of Acetaminophen tablets has been determined. The disintegration directly related with the hardness of the tablets. The tablets were prepared using lactose as diluent and with different levels of disintegrants like Na Cmc and Avicel. The tablets were evaluated for weight variation, hardness, friability, disintegration time (DT) and dissolution study. The tablets were prepared by using wet granulation method and were evaluated in the similar way. Percentage drug release was estimated by using UV spectrophotometry method .The hardness, friability, dissolution rate and assay of prepared tablets were found to be acceptable according to standard limits of IP official pharmacopeias.