DENSITY AND VISCOSITY STUDIES OF PARACETAMOL IN ETHANOL + WATER SYSTEM AT 301.5 K

Abstract

Density and Viscosity of drug Paracetamol (PAM) in various aqueous mixtures of ethanol have been determined. These results are further extended for solutes like electrolyte NaCl and non-electrolyte sucrose in the presence of this drug. The density and viscosity data have been analyzed for the evaluation of partial molar volume, molar excess volume, excess viscosity and A 8 B viscosity coefficients using Jones-Dole equation. It can be inferred from these studies that this drug acts as a structure-making compound due to hydrophobic hydration of drug molecules. B-coefficients values are found to be positive thereby showing drug solvent interactions. Furthermore these results are correlated to understand the solution behavior of drug.