SYNTHESIS, SPECTRAL CORRELATION STUDY, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF SUBSTITUTED 5-(4-FLUOROPHENYL)-3-PHENYLISOXAZOLES

Abstract

Different substituted 5-(4-fluorophenyl)-3-phenylisoxazole compounds have been synthesized by condensation of substituted chalcone compounds using the hydroxylamine hydrochloride. The isoxazole compound structures are confirmed by various spectral analyses.These 5-(4-fluorophenyl)-3-phenylisoxazoles have been characterized from the physical constants, UV, FT-IR, 1H and 13C Nuclear magnetic resonance spectral data. The above compound spectral values correlated by using the Hammett constants and Swain’s Lupton parameters. The microbial activities of the synthesized isoxazole were evaluated.