SYNTHESIS AND SPECTRAL LINEARITY STUDIES OF SOME THERAPEUTICALLY INTERESTED SUBSTITUTED HYDRAZONES

Abstract

In the present work, we report the synthesis of substituted (E)-2-benzylidene-1-methylhydrazines by reaction of substituted aldehydes with 1-methylhydrazine in the presence of acetic acid using as catalyst. The synthesized compounds are more than 80% yield. UV, IR and NMR spectral data have been used to identify the structure of synthesized compounds. UV, IR and NMR spectroscopic data of substituted (E)-2-benzylidene-1-methylhydrazines have been correlated with Hammett constants and F and R parameters using linear regression analyses. From the results the effect of substituents has been discussed. The antimicrobial assay of these (E)-2-benzylidene-1-methylhydrazines compounds were studied using Kirby-Bauer method.