FORMULATION AND EVALUATION OF LIPOSOMES OF INDOMETHACIN

Abstract

Liposomes are spherical shaped vesicles having 0.05- 5.0 micrometer in diameter consist of phospholipids and cholesterol. This novel drug delivery system aims to target the drug directly to the site of action. Liposomes are biocompatible and stable and have unique property to entrap both hydrophilic drug and lipophilic drug. The aim of the present study is to formulate and evaluate the liposomes of Indomethacin using HPMC, PVP, Sodium lauryl sulphate which leads to increase the solubility. Various formulations from LS1 to LS7 of Indomethacin Liposomes were developed using different concentrations of polymers like PVP, HPMC etc. The Liposomes were prepared by thin film hydration method. Liposomes were characterized by polymer compatibility by using spectral analysis of drug. The prepared Liposomes were evaluated for solubility, viscosity determination, entrapment efficiency in vitro drug release and stability studies. Finally, batch LS1 is concluded as optimum formulation.