ULTRASONIC INVESTIGATION OF ION-SOLVENT INTERACTIONS OF DRUG IN NON-AQUEOUS MEDIUM

Abstract

The study of molecular interactions in the solutions and liquids are of considerable importance and has been undertaken by many researches now-a-days. Many physical methods are employed to study the physical properties of liquids/solutions. They are ultrasonic, thermodynamic, thermochemical and spectroscopic methods. Ultrasonic velocity measurements are highly sensitive to molecular interactions and used to provide qualitative information about the nature and strength of the intermolecular / inter- ionic interactions. Diseases in human beings and animals may be caused by a variety of microorganisms. Antibiotics, antiseptic and disinfectants are prescribed as drugs. The drug-solvent interactions play an important role in the understanding of drug action. The term “Sulfanilamides” (Sulphanilamide) is also used to describe a family of molecules containing these functional groups. Sulphanilamide reduces vaginal burning, itching and discharge that may occur with this condition. Sulfamerazine is also a sulfonamide antibacterial agent. It is bacteriostatic in nature. Inhibition of dihydrofolic acid synthesis decreases the synthesis of bacterial nucleotides and DNA. In the present investigation, the solutions of different molalities were prepared with the samples in non-aqueous medium and the experiments were carried out from low concentration to higher concentration, at different temperatures. The measured values of density, viscosity and ultrasonic velocity were used to compute adiabatic compressibility and specific acoustic impedance. An attempt is made to identify the entry solvate into the samples and the entry of biological molecules into the solvate which supports to identify the molecular structure. From the experimental data of ultrasonic velocity, density and viscosity, calculated the acoustical parameters.