WOUND HEALING EFFICACY OF GREEN SYNTHESIZED SILVER NANOPARTICLES FROM TECTONA GRANDIS WOOD FLOUR EXTRACT IN WISTAR RATS

Abstract

Wound healing is a physiological process in which the tissue repairs itself after injury. Wound healing has attained a lot of attention as it is a complex phenomenon to maintain the integrity of skin after trauma. Stimulated wound closure without formation of scar or a faint scar is of great interest of dermatologist. Silver has been used to treat burns, wounds and infections in various forms. The tremendous developments in nanotechnology provide opportunities to modulates the metals into the nanosize and enhance their physical, chemical and physiological properties. Metallic silver in form of silver nanoparticles (AgNP) has been earlier reported to possess strong antimicrobial and antioxidant properties. Green synthesis is advancement in nanoparticle synthesis. In the present study, the effect of formulated nanoparticles using Tectona Grandis wood floor extract (green synthesized) was evaluated for ameliorating excision wounds in rats. AgNPs were synthesizes using an extract of Tectona Grandis wood floor extract as a reducing agent. The wound healing activity of AgNP in excision wound model in Wistar male rats was remarkable and equivalent to standard soframycin treatment. The results show amelioration of excision wounds using green synthesized AgNP could be a novel therapeutic way of improving wound healing in clinical practice.