EFFECT OF 6-GINGEROL ON THIOUREA INDUCED TOXICITY OF LUNGS IN ALBINO RATS

Abstract

Pesticides are known for their persistence in the environment along with products of their biotransformation, remaining in and interacting with the environment and living organisms in multiple ways, depending upon their nature and chemical structure, dose and target. The protective effect of 6-gingerol on thiourea induced lung damage in rats has been elucidated in the present study, wherein Wister strain male rats of 200-250gm were selected and divided into 4 groups of 4 animals each. One group given normal saline and treated as control, second group given 0.1 mg/100gm body weight(BW) thiourea, while third was given 0.5 mg/100gm BW 6- gingerol alone and fourth group was given both thiourea and 6-gingerol at mentioned dosage. Experimental setup maintained for 180 days and then sacrificed. Lung tissue dissected and fixed for histological studies. Reduction in body weight as well as lung weight observed, while supplementation with 6-gingerol was observed to bring about improvement in lung and body weight. Granulation, thickening of alveolar walls with inflammation and oedema observed on thiourea induction, while 6-gingerol alone brought about slight inflammation and thickening of alveolar walls. Supplementation of 6-gingerol to thiourea induced group was observed to reduce oedema, lessing of inflammation, thus proving its beneficial effect in alleviating thiourea induced toxicity of the lung.