FORMULATION AND EVALUTION OF DOXYCYCLINE IN-SITU FILM FOR THE TREATMENT OF PERIDONTITIS

Abstract

The periodontal disease is confirmed by a group of illnesses affecting the gums and dental support structures. They are caused by certain bacteria found in the bacterial plaque. Doxycycline broad-spectrum antibiotic of the tetracycline class generally prescribed in the treatment of periodontitis for localized therapy. In present work, in-situ film of Doxycycline was prepared. The in-situ film was formulated using biodegradable polymer like pectin, xanthan gum and acacia. Gels were prepared by dissolving biodegradable polymer in hydro alcoholic solvent along with PEG 400 as plasticizer. Then gel is applied to gums which convert into the film (in-situ) by solvent evaporation mechanism. The prepared drug loaded gels and in-situ film were subjected for various evaluation parameters like speradability, pH, viscosity, thickness of film, weight uniformity, percent moisture loss, drug content respectively. Experimental result revealed that viscosity of gel 1745.65±0.14 to 1958.18±0.28cps, pH of gel range between 6.56±0.124 to 6.75±0.169, value of spreadability index was in between 17.25±0.28to 19.81±0.17 cm2, thickness of film were less than 0.2mm, weight uniformity0.052±0.002 to 0.055±0.001gm, percent moisture loss 5.264±1.958 to 5.969±1.845%. From experiment study it was concluded that doxycycline in-situ film was provided better retention, hence effective for local delivery of doxycycline which may improved patient compliance and effective management of periodontitis.