FORMULATION AND EVALUATION OF COLON TARGETED CHRONOMODULATED DRUG DELIVERY OF DOXOFYLLINE FOR THE TREATMENT OF NOCTURNAL ASTHMA

Abstract

The main purpose of present investigation was to formulate and evaluate a colon targeted chronomodulated drug delivery system of drug to achieve it’s time specific release. Colon targeted drug delivery delivers the drug at specific site where in both local and systemic drug delivery can take place. Various novel approaches for colon targeted drug delivery include prodrug, pH 8 time dependent systems, and microbially triggered system. Chronomodulated drug delivery system are of interest as they deliver the drug at right site of action at the right time and in the right amount which provides more benefits than conventional dosage forms and increasing patient compliance. This system based on the circadian rhythms of the body and the release of the drug as a pulse after lag time has to be developed in such a way that a complete and rapid drug release follows the lag time. Core tablet was prepared by using xanthan gum, sodium starch glycolate, magnesium stearate and talc by direct compression. Tablets were further coated with pH sensitive polymer like HPMC K4M by compression coating technique and enteric coated tablet was prepared by Eudragit L100. Finally the tablet was coated with the organic solvent ethanol, acetone by using dip coating technique. Tablets were evaluated for hardness, friability, weight variation, drug content and in vitro drug release. The hardness of tablet was found to be 5.2±0.83 to 4.0±0.55, friability 0.45±0.07 to 0.29±0.04 and weight variation 450±0.46 to 282±0.29. The lag time (t10) and percentage drug release at 7.9 hour and time required for release 87.9 of drug were selected.