PREPARATION AND CHARACTERIZATION OF pH-RESPONSIVE TRANSFEROSOMES FOR TRANSDERMAL DELIVERY OF PACLITAXEL

Abstract

Transferosomes are phospholipids vesicles as transdermal drug carriers that enhance the therapeutic efficacy of anticancer agents with high efficiency. In present study, Paclitaxel (PTX) was derivatized at its 2′-hydroxy function by esterification with amino acids using thin film hydration technique accompanied by sonication. Prepared pH-responsive transferosomes (pRTs) were optimized with drug conjugate: lipid ratio and characterized with respect to size, shape, surface charge, entrapment efficacy pH responsiveness, and drug release. Results of the studies indicated that optimized parameters of selected pRTs (Formulation code: F2S4C2S4) with respect to vesicle size, PDI, zeta potential, percent entrapment efficiency and turbidity were as 147.5nm, 0.187, -13mV, 71.04% and 460 NTU, respectively. In conclusion, the optimized transferosomes has demonstrated prolonged drug release effect at different pH level. The developed and optimized transferosomes containing PTX can be administered transdermally for the treatment of cancer disease with maintaining lower side effect improved patient compliance.