SYNTHESIS AND BIOLOGICAL SCREENING OF NEW AZASPIRO [2, 4] HEPTANECARBOXYLATE DERIVATIVES

Abstract

Spiro ring molecules including their derivatives are found to be handy intermediates in the fusion of medicinally active molecules. In recent years due to many interesting biological activity applications associated ample attention by the researchers has been given to spiro compound. Many spiro compounds contain nitrogen. The work aims at ground work of methyl- 5-(1-4- substituted phenyl ethyl)-5-azaspiro [2, 4] heptane-6-carboxylate react with methyl [({1- [acetyloxy) methyl] cyclopropyl} methyl) (1-phenylethyl) amino] acetate along with NaH and toluene to find out most favorable reaction conditions and additional study of its properties. The synthesized compounds were characterized by 1H NMR; C13 NMR was dogged in CDCl3/dimethyl sulfoxide solution on a Bruker Ac 400 MHz spectrometer.