SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF MANNICH BASES OF 1,3,4-OXADIAZOLE DERIVATIVE

Abstract

A novel series of substituted 1,3,4-oxadiazole derivative were synthesized by condensing different amine with 5-(1-(4- isobutylphenyl)ethyl)-1,3,4-oxadiazole-2(3H)-thione (III) in presence of formaldehyde. The structure of these novel synthesized compounds was characterized on the bases of physicochemical, spectral and elemental analysis. All newly synthesized compounds were tested in vivo for their anti-inflammatory activity by carrageenan induced rat paw oedema model. The compounds, which showed good anti-inflammatory activities were further screened for their analgesic, antipyretic and ulcerogenic activity. Results of acute anti-inflammatory studies showed compounds IVa, IVb, IVc and IVe showed promising activity and in analgesic studies compound IVa, IVc and IVe showed better activity as compared to standard drug ibuprofen. Compounds IVa and IVb showed good antipyretic activity and less ulcerogenic activity as compared to standard drug ibuprofen.