SYNTHESIS AND PHRAMACOLOGICAL EVALUATION OF 3-(1-NAPHTHYL)-1-SUBSTITUTED PHENYL CHALCONES AS POTENT ANTIMICROBIAL AGENTS

Abstract

About ten numbers of (E)-3-(1-naphthyl)-1-substituted phenyl chalcones have been synthesized using microwave assisted Crossed-Aldol condensation of various acetophenones and 1-naphthaldehyde in the presence of Fly-ash:H3PO4 nano catalyst under solvent-free conditions. This methodology produced more than 90% yields. These ketones were characterized by their physico chemical quantities, micro analysis and spectroscopic data. The antimicrobial activities of these compounds have been assessed by Bauer-Kriby disc diffusion technique. From the measurement of the zone of the inhibitions against the microbes, the antibacterial and antifungal activities of these ketones were discussed.