INTERPENETRATING POLYMER NETWORK MICROSPHERES OF POLY (VINYL ALCOHOL)/XANTHAN GUM FOR CONTROL RELEASE OF VERAPAMIL HYDROCHLORIDE

Abstract

Xanthan gum(XG) and Poly (vinyl alcohol) (PVA) interpenetrating polymer network(IPN) microspheres were prepared by water in oil emulsion method, loaded with Verapamil Hydrochloride (VMHCl) drug further crosslinked with glutaraldehyde (GA). These microspheres were prepared with various ratios of XG, PVA, drug, cross linker and these were characterized with various techniques. The prepared microspheres with loose and rigid surfaces were evidenced by scanning electron microscopy (SEM).Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis confirmed the IPN formation. Differential scanning calorimetry (DSC) study was performed to understand the dispersion nature of drug after encapsulation. In vitro dissolution experiments were performed in pH 7.4 buffer medium at 37˚C. All the formulations exhibited satisfactory physicochemical and in vitro release characteristics. Release data indicated a non-Fickian trend of drug release from all the formulations. Based on the results, this study suggests that VMHCl loaded XG/PVA IPN microspheres were suitable for sustained release application.