ANTIMICROBIAL ACTIVITY OF NEW SERIES OF BENZOTHIOPHENE CONTAINING THAIZOLIDINONE DERIVATIVES

Abstract

Thiazolidinones have become an important class of heterocyclic compounds since their introduction in the form of glitazones into the clinical use for the treatment of diabetes. In addition, this class of heterocyclic compounds possesses various other biological activities such as antihyperglycemic, antimicrobial, anti-inflammatory, anticonvulsant, insecticidal, etc. In the present study thaizolidinone derivatives containing benzothiophene moiety synthesized in our previous study have been evaluated for their antibacterial and antifungal activity against three bacterial Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and three fungal strains Candida albicus, Aspergillus niger, Aspergillus fumigatues using cup or well method. These compounds have exhibited very encouraging results showing inhibition zone from 10 mm to 16 mm against three bacterial strain and from 14 mm to 23 mm against fungal strain which is much closer to zone of inhibition of standard Ciprofloxacin and Griseofulvin respectively.