Difference in Rate of Reaction of Some Thiazolidinone Derivatives with Synthesis and Spectral Characterization

Abstract

A series of substituted 5-ethylidene-2-(phenylimino) thiazolidin-4-ones were prepared by using phenylthiourea (I) as a starting material. Phenylthiourea on reaction with ethylchloroacetate in presence of ethanol (95%) and fused sodium acetate gives 2-(phenylimino) thiazolidin-4- one (II), 2-(phenylimino) thiazolidin-4-one on further reaction with substituted benzaldehyde gives substituted 5-ethylidene-2-(phenylimino) thiazolidin-4-one (III-XI). Synthesized compounds were authenticated on the basis of elemental analysis, IR and 1H NMR and Mass spectral analysis