The Antiulcer Activities of the Methanol Extract of Cassia singueana Leaves Using Indomethacin-Induced Gastric Ulcer Model in Rats

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O. J. Ode

Abstract

The antiulcer activities of the methanolic extract of Cassia singueana leaves were evaluated using indomethacin-induced gastric ulcer model in rats. The extract was prepared by cold marceration in 80% methanol at 370C with intermittent shaking for 48 h. A yield of 12.6% w/w dry extract was obtained. The extract was safe, up to a dose of 4000 mg/kg given per os did not cause mortality in the rats. The extract at 250 and 750 mg/kg produced significant (p less than 0.05) protective effect in rats with a preventive index of 71% against 52% with cimetidine (100 mg/kg) and 0% with distilled water. The histopathologic lesions deviated from numerous severe focal lesions and marked disorientation of the gastric epithelium in solvent treated control to fairly protected gastric mucosa with CSE (250 and 750 mg/kg) and cimetidine (100 mg/k) treated rats. Cassia leaf extract was found to be significantly protective against indomethacin-induced gastric ulcers in the experimental rats.

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How to Cite
Ode, O. (2011). The Antiulcer Activities of the Methanol Extract of Cassia singueana Leaves Using Indomethacin-Induced Gastric Ulcer Model in Rats. Journal of Advanced Scientific Research, 2(03), 66-69. Retrieved from https://sciensage.info/index.php/JASR/article/view/47
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Research Articles