INCIDENCE AND SENSITIVITY PATTERN OF PSEUDOMONAS AERUGINOSA IN PATIENTS OF ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Abstract

This study was taken up to find out incidence and sensitivity pattern of Pseudomonas aeruginosa in patients hospitalized in J. N. Medical College, A.M.U., Aligarh for AECOPD (acute exacerbation of chronic obstructive pulmonary disease) as knowledge of possible sensitivity patterns facilitates the orientation of antibacterial treatment. The most common cause of AECOPD is an upper respiratory infection caused by an increase in airway bacterial load or the emergence of a new bacterial strain. In addition, viral infections, air pollution and some unidentified pathogens can also cause AECOPD. 200 clinically diagnosed cases of AECOPD of age ≥40 years were included in the study. Sputum sample was obtained from the patients and processed according to standard lab procedures. The prevalence of AECOPD was more common in the age group of 50-60 years (49.5%) with ratio between male and female of 2.8:1. Among 200 patients hospitalized for AECOPD Pseudomonas aeruginosa incidence was found to be 20.7%, isolated organism were sensitive to Amikacin, Piperacillin tazobactum, Levofloxacin and Meropenem. However a high level of resistance was seen with Ceftazidime, Aztreonam and Cefixime.