COMPARATIVE STUDY OF GLYCOGEN PHOSPHORYLASE BB AND CREATINE KINASE MB AT FIRST HOUR AFTER OF ACUTE MYOCARDIAL INFARCTION

Abstract

Acute myocardial infarction (AMI) results from the intervention of blood supply to the heart, due to this heart cells to die. It is the leading cause of mortality and morbidity in present days. Chest pain is the most common symptom in majority of the patients with AMI. Cardiac markers are released during chest pain. So there is an emerging need to detect for early, specific cardiac markers. Glycogen phosphorylase BB (GPBB) is potential marker of chest pain and myocardial infarction. Objective of the study was to compare the sensitivity and specificity of GPBB and CKMB at 1st hour after of acute myocardial infarction. Blood samples from 80 AMI patients and 50 age and sex matched healthy controls were collected and analyzed for cardiac enzymes CK-MB (by automated analyzer) and GPBB (by ELISA reader). GPBB had released after 1 hour and higher peak value after 3 h of chest pain in AMI patients. The receiver operating characteristic curves was significantly greater for GPBB when compare with CKMB in AMI patients. GPBB is considerably sensitive and specific at the first hour of admission in AMI patients. It is elevated in all of the AMI patients.