MEAN PLATELET VOLUME: A MEASURE OF PLATELET ACTIVITY AND ITS RELATION WITH OTHER PLATELET INDICES IN DEEP VEIN THROMBOSIS

Abstract

Several parameters may help in identification of DVT. Several studies proposed that larger mean platelet volume (MPV) is an indicator of increased in vivo platelet activation. The MPV correlates with platelet activity whether measured as aggregation, thromboxane A2 (TXA2) or 3-thromboglobulin (β-TG) release, or adhesion molecule expression. A total number of 33 cases and 33 controls were included in this study. We included all patients who were positive for acute DVT as confirmed by Duplex scan. Patients on antiplatelet/anticoagulant therapy were excluded from the study. Clinical assessment of all patients, detailed history and physical examination was performed and recorded in proforma. 2ml of blood collected in lavender top vials containing K2EDTA and analyzed in Beckmann Coulter fully automatic analyzer. Mean of MPV of all cases was 9.9fL and mean of MPV of all controls was 9.1fL. MPV was found to be raised in cases when compared to controls which was statistically significant with p-value=0.004. Mean platelet volume is a marker of platelet activation and is raised in DVT patients when compared to healthy individuals.