SYNTHESIS OF MICELLES GUIDED CO-FERRITE PARTICLES AND THEIR APPLICATION FOR AC MAGNETIC FIELD STIMULATED DRUG RELEASE

Abstract

Cobalt ferrite magnetic nanoparticles of two different sizes about 250 nm and 350 nm have been prepared by coprecipitation method using oleic acid as micelles. Particles prepared in this process changes their size with change of micelles concentration. With change of oleic acid concentration, number of micelles formed changes and for higher concentration higher number of micelles and for lower concentration lower numbers of micelles are formed which function differently during growth of particles and hence helps in size change of particles by changing nucleation of the particles initially formed. Structural analysis of the particles was done by XRD measurement and morphological study was performed by SEM measurement. DC and AC magnetic property of the particles have also been studied. The particles have shown their application in drug release by stimuli responsive technique. AC magnetic field stimulated drug release event by these particles provide a direction of the promising application of these particles for better localized cancer treatment in near future.