SYNTHESIS AND ANTIMICROBIAL EVALUATION OF N'-ARYL-3-(4,5-DIPHENYLOXAZOL-2-YL)- PROPANEHYDRAZIDES

Abstract

A simple, efficient and environmetally benign method was developed towards the synthesis of a series of N'-aryl-3-(4,5- diphenyloxazol-2-yl)- propanehydrazides 4a-4j catalyzed by meglumine. All the substares were obtained in good yields under moderate reaction conditions. The precusor 3-(4,5-diphenyloxazol-2-yl)propanehydrazide is obtained in excellent yields from 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid. All the prepared hydrazones were characterized by IR, 1H NMR, 13C NMR and Mass analysis. Furthermore, the compounds 4a-4j were also screened for their antimicrobial activity. The anti-microbial activities of the prepared compounds were investigated against four bacterial strains: Xanthomonas campestris, Escherichia coli, Bacillus cereus, Bacillus megaterium and a fungal strain Candida albicans. The biological evaluation studies of these N'-aryl-3-(4,5-diphenyloxazol-2-yl)- propanehydrazides revealed that some of these test compounds possess moderate in vitro antimicrobial activity.