SYNTHESIS AND ANTIMICROBIAL EVALUATION OF N'-ARYL-3-(4,5-DIPHENYLOXAZOL-2-YL)- PROPANEHYDRAZIDES
Main Article Content
Abstract
A simple, efficient and environmetally benign method was developed towards the synthesis of a series of N'-aryl-3-(4,5- diphenyloxazol-2-yl)- propanehydrazides 4a-4j catalyzed by meglumine. All the substares were obtained in good yields under moderate reaction conditions. The precusor 3-(4,5-diphenyloxazol-2-yl)propanehydrazide is obtained in excellent yields from 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid. All the prepared hydrazones were characterized by IR, 1H NMR, 13C NMR and Mass analysis. Furthermore, the compounds 4a-4j were also screened for their antimicrobial activity. The anti-microbial activities of the prepared compounds were investigated against four bacterial strains: Xanthomonas campestris, Escherichia coli, Bacillus cereus, Bacillus megaterium and a fungal strain Candida albicans. The biological evaluation studies of these N'-aryl-3-(4,5-diphenyloxazol-2-yl)- propanehydrazides revealed that some of these test compounds possess moderate in vitro antimicrobial activity.
Downloads
Download data is not yet available.
Article Details
How to Cite
Boddapati, S. N., Kola, A., & Tadeti, K. (2020). SYNTHESIS AND ANTIMICROBIAL EVALUATION OF N’-ARYL-3-(4,5-DIPHENYLOXAZOL-2-YL)- PROPANEHYDRAZIDES. Journal of Advanced Scientific Research, 11(03), 233-238. Retrieved from https://sciensage.info/index.php/JASR/article/view/532
Section
Research Articles
![Creative Commons License](http://i.creativecommons.org/l/by-nc-nd/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.