SOLVENT FREE SYNTHESIS AND CHARACTERIZATION OF SOME BIOACTIVE METAL COMPLEXES OF SCHIFF BASE LIGAND DERIVED FROM 2-AMINO-5, 6-DIMETHYL BENZIMIDAZOLE AND 4, 4’-DIBROMO BENZIL

Abstract

A tetra dentate Schiff base ligand was synthesized by treating 2-Amino-5, 6-dimethyl benzimidazole with 4, 4’-dibromo benzil under solvent free condition in 2:1 molar proportion in a scientific microwave oven. Yield obtained was very high after purification of synthesized product. Some transition metal complex of this synthesized Schiff base ligand were prepared by using Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Ag(I) metal salts in microwave oven under solvent free condition. The metal complexes formed were confirmed by their distinguishing color and exact melting point. Schiff base ligand was further characterized by TLC, elemental analysis, IR spectroscopy, LCMS and 1H NMR Spectroscopy. The metal complexes were identified by TLC and representatively characterized by IR spectroscopy, UV spectroscopy and DSC. Both Schiff base ligand and its synthesized metal complexes screened for bioactivity study against Escherichia Coli, Staphylococcus Aureus 8 Salmonella Typhi by MIC measurement. MIC study clearly indicates Fe (III) complex 8 Cu (II) complex displays highest activity against Escherichia Coli, Cu (II) complex 8 Ag (I) complex displays highest activity against Staphylococcus Aureuswhereas Co (II) complex displays highest activity against Salmonella Typhi compared to novel ligand and rest of the metal complexes.