SARS-COV-2: A STUDY IN LIGHT OF OTHER HUMAN CORONAVIRUSES

Abstract

Four mild human coronaviruses (HCoVs), viz. HCoV-229E, HCoV-OC43, HCoV-HKU1, and HCoV-NL63 have already been prevailing in the human population causing mild respiratory diseases. Thereafter, the two major human infecting coronaviruses responsible for the production of symptoms that are potentially severe and cause a widespread infection, MERS-CoV and SARS-CoV, came into human notice; and now in December 2019, another species called Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been a cause of major nuisance created all over the world. For a thorough analysis of SARS-CoV-2 and its pathogenicity, it is required to study about the past events of various other human coronaviruses’ emergence. A systematic and relative review of Human Coronaviruses based upon their origin, epidemiology, pathogenicity, molecular aspects, lifecycle as well as antiviral strategies considering the current Coronavirus disease 2019 (COVID-19) pandemic would be of great help in a better understanding of SARSCoV- 2.