FORMULATION AND IN-VITRO EVALUATION OF CARBAMAZEPINE NANOSPONGE

Abstract

The main purpose of this investigation study was to fabricate nanosponges with good entrapment efficiency and percentage of yield to enhance the solubility and dissolution rate of poorly water-soluble antiepileptic molecules of Carbamazepine. Molecule was selected as the choice of drug as it belongs to BCS class II with low solubility and high permeability. Carbamazepine nanosponges were prepared to enhance the solubility and dissolution rate using the Emulsion solvent diffusion technique. Nanosponges were formulated using different polymers ratio like Ethyl cellulose and polyvinyl alcohol. The batch-containing ratio 2:1:2 of Drug, Ethyl cellulose and PVA gave maximum entrapment efficiency and percentage of yield. Reduced size up to nano levels of nanosponges are confirmed through particle size analysis. Optimized nanosponges were further mixed with common excipients and compressed in to oral tablets. The optimized nanosponges were subjected for Practical yield, Drug content, Saturation solubility, Zeta potential (ZP), Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), X-ray powder Diffractometry and Scanning electron microscopy (SEM). Pre and post compression parameters were also studied. FT-IR revealed no chemical incompatibility between drug and polymer. Solubility and increase in dissolution rate as compared to the plain drug were also demonstrated for nanosponge formulation. The tablets of Carbamazepine nanosponges were successfully prepared and the formulation was found to be stable.