COPPER CATALYZED EFFICIENT SYNTHESIS OF 1,2,3-TIAZOLE DERIVATIVES FROM CHALCONE AND BENZYL AZIDE BY 1,3-DIPOLAR CYCLOADDITION REACTION STRATEGY

Abstract

An efficient copper sulphate catalyzed one pot 1,3-dipolar cycloaddition reaction strategy has been developed for the synthesis of some 1,2,3-triazole derivative from chalcone and benzyl azide by refluxing in toluene. The progress of the reaction was studied in different polar and non polar solvents and the reaction was generalized by using differently substituted chalcones. Yields of all the reactions were excellent and no undesired side products were formed; moreover, the catalyst can be recycled and reused. The structures of the end products were confirmed by IR, 1H, 13C and mass spectrometric analyses.