EVALUATION OF EFFECT OF ETHANOLIC EXTRACT OF FAGONIA CRETICA L. PLANT AGAINST EXPERIMENTALLY INDUCED ULCERATIVE COLITIS IN MICE

Abstract

Fagonia cretica L. is conventional herb medication that is broadly utilized in clinical health care. The clinical functions of Fagonia cretica L. include immunomodulatory, anti-inflammation, anti-microbial, hepatoprotective activity. In spite of the fact its effects on inflammation of the colon remains undefined. We examined the effects of Ethanolic extract of Fagonia creica L. (EEFC) plant in dextran sulfate sodium (DSS) induced ulcerative colitis in mice. DSS (2%) was given orally in drinking water for 7 days to induce ulcerative colitis. Change in body weight, food intake, water intake was calculated every day. The degree and seriousness of ulceration was examined macroscopically using a disease activity index (DAI). After 9th day, colon mucosal damage index (CMDI), colon weight 8 length, myeloperoxidase (MPO), an exact marker of inflammation and antioxidants parameters (MDA, SOD, CAT) was evaluated. EEFC (400 mg/kg) significantly improved the body weight, colon length of the animals as compared to the disease control group. Animal treated with EEFC (400 mg/kg) showed significantly improved CMDI (1.40±0.27) 8 DAI (1.28±0.23) as compared to the disease control group CMDI (3.40±0.39), DAI (3.87±0.11). Higher level of SOD and Catalase and lower level of MDA were observed in animals treated with EEFC (400 mg/kg) as compared to disease control group. Animals treated with EEFC (400 mg/kg) significantly decreased in MPO level as compared to disease control group. The anti ulcerative effect of extract of Fagonia cretica L was comparable to sulphasalazine (100 mg/kg, p.o.) as standard. The outcomes recommended the defensive capability of EEFC in DSS-instigated colitis and this may be credited to its phytoconstituents that have been found to initiate a wide range of this study, for example, EEFC has substantial potential for the treatment of inflammatory colitis.