Anticonvulsant and Comparative Structure Activity Relationship of Pyridazine Derivatives with Currently Clinically Used Anticonvulsants

Abstract

There has been considerable interest in the development of novel pyridazine and pyridazinone compounds with their anticonvulsant activity. Pyridazine and pyridazinones possessing a magic azometine –NH-N=CH- moiety. The pyridazinone also possessing cyclic amide moiety in their ring structures, constitute an important class of compounds for new drug development and the effect of a hydrophobic unit, hydrogen bonding domain and electron-donor group on the compound’s anticonvulsant activity. Therefore, many researchers have synthesized these compounds as target structures and evaluated their different pharmacological activities. These observations have been guiding for the development of new pyridazinones that possess potent anticonvulsant activity with less toxic or side effects.