STRAIGHTFORWARD MULTICOMPONENT SYNTHESIS AND MICROBIAL SCREENING OF 2-CYANOAMINO-1, 2-DIHYDROPYRIMIDINES BEARING INDOLE SIDE CORE

Abstract

A new class of Indole connected cyanoaminopyrimidine scaffolds were synthesized by Multicomponent single-pot strategy with the reaction of indole-3-carbaldehyde, substituted acetophenone and cyanoguanidine in a basic alcoholic medium. The structural assignments were done for the obtained 2-Cyanoamino-6-aryl-4-(indol-3-yl)-1,2-dihydro-1Hpyrimidines (4a-4f) with the help of 1H,13C NMR, IR and Mass spectral data. The screened in vitro microbial activities of most of the compounds showed moderate to strong anti-microbial potential.