ATTENUATION OF HYPERALGESIA AND ALLODYNIA BY SOME PHENOLIC ACIDS IN PACLITAXEL INDUCED NEUROPATHY

Abstract

Paclitaxel, an anticancer drug induced neuropathy is widely used animal model to evaluate new drugs in neuropathy. As oxidative stress is key contributor in pathogenesis of neuropathy, many phenolic acids with antioxidant potential are proven as neuroprotective. So, present work was undertaken to evaluate effect of syringic acid and sinapic acid in paclitaxel induced neuropathy. We evaluated effect on mechanical and thermal hyperalgesia and allodynia which are vital signs of neuropathy. Four weeks treatment by different doses of syringic acid and sinapic acid showed significant protective effect on hyperalgesia and allodynia in dose dependant manner assessed by Randello Selitto, hot plate, cold plate and Von Frey filament test. As these phenolic acids attenuate hyperalgesia and allodynia in neuropathy, can be therapeutically used in combination with current treatment of neuropathy.