SILVER NANOPARTICLE INCORPORATED GEL FOR TOPICAL BACTERIAL TREATMENT

Abstract

Numerous pathogenic bacteria are developing antibiotic resistance. Improvement from multidrug resistant (MDR) infections is a problematic issue and requires a multiple treatment with broad-spectrum antibiotics which are less efficient, more toxic and more expensive. Silver nanoparticles (AgNPs) are attracting much attention because of their potent antibacterial and anti-biofilm activities. These nanoparticles are lengthily synthesized and used as a successful broad spectrum antibacterial agent against Gram negative and Gram positive bacteria including antibiotic unwilling bacteria. Silver attacks multiple targets in the microorganism consequently decreases its ability to develop battle. Effect of coating on AgNPs constancy, toxicity on the microbial host and their antimicrobial activity was discussed. The amalgamation of AgNPs into hydrogels magnifies the antibacterial activity according to their characteristics; hydrogels work as an competent stabilizer of AgNPs and control the release of AgNPs. In the present review, the silver nanoparticles-hydrogel and their components as well as their antibacterial activities and wound healing efficacies are reviewed and discussed on the bases of constituent variabilities and characteristics. Different factors and topics are measured since there are challenges and challenging issues need to be faced and solved for expansion of new ideal antibacterial formulation.