INHIBITION OF AMYLOID BETA FIBRILIZATION BY SMALL ORGANIC MOLECULES: AN IMPLICATION TO THERAPEUTIC ROUTE OF ALZHEIMER’S DISEASE

Abstract

The exact reason of Alzheimer’s disease is still not understood but deposition of extracellular plaques formed by the aggregation of amyloid β peptide and intracellular accumulation of neuro fibril tangles (NFT) formed by phosphorylated tau protein are the two hall marks of Alzheimer’s disease. Therapeutic route to Alzheimer’s disease is still unknown. Studies with natural products, short peptides and synthetic organic molecules have identified a pool of small organic molecules with aggregation inhibitory activity. These molecules can be considered as lead compounds in the drug discovery of Alzheimer’s disease.