IN SILICO HOMOLOGY MODELING OF SYSTEMIN RECEPTOR SR160 - THERAPEUTICAL TARGET FOR THE INDUCTION OF THE CELLULAR DEFENSIVE GENE

Abstract

Systemin receptor (SR160) is a plasma membrane bound receptor protein, work as key regulatory signals for the activation of defensive mechanism in tomato plants. It has been confirmed that systemin is plant peptide hormone containing 18 amino acids, binds with its known receptor SR160 to activate the downstream cascade pathway for the activation of defensive genes in tomato. 3D structure of SR160 was not available so homology modeling was preferred to generate the good quality model. For the verification of the model procheck was used. The predicted model can be for the prediction of binding interaction and structure-based drug designing.