SYNTHESIS, STRUCTURAL ANALYSIS AND PHOTOPHYSICAL PARAMETERS OF ISOXAZOLINE DERIVATIVES

Abstract

In the present work, series of 5 substituted isoxazolines have been synthesized by reacting appropriate chalcone with hydroxylamine hydrochloride. The structures of synthesized compounds were confirmed by IR, NMR and Mass spectral analysis. The aim of this work is to synthesize and characterize new isoxazoline derivative. Also study was extended to antimicrobial activity, photophysical property, viscometric measurement and its thermodynamic parameter like Entropy, Enthalpy and Gibbs free energy at different concentrations. The maximum absorption of synthesized derivative -3(4’ methyl phenyl)-5-(furan) isoxazoline was found at 311nm. The study shows positive value of ΔS, negative value of ΔG and positive value of ΔH which confirms that the reaction is endothermic and spontaneous. It was also observed that viscosity of solution increases with increase in the concentration of solution and positive value of B-coefficient may attribute to strong solute-solvent interaction. On the other hand value of A-coefficient is almost negative which indicates weak solute-solute interaction.