SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL (E)1-[4-((6-CHLORO-PYRIDAZINE-3-YL)AMINO)-PHENYL]-3-PHENYL-PROPENONE DERIVATIVES

Abstract

Some new chalcone enabled pyridazine analogues were synthesized via reaction between substituted aromatic aldehyde and 3, 6-disubstituted pyridazine ring. The final compounds were screened for antimicrobial activities by in vitro method. Prepared novel series of pyridazine derivatives showed promising and encouraging results in view of antimicrobial studies with E.Coli, S.Aureus, A.Niger and B. Albicans.