EVALUATION OF THE PHARMACOLOGICAL PROPERTIES OF SCHIFF BASE MIXED LIGAND Cu(II), Co(II) AND Ni(II) COMPLEXES DERIVED FROM (E)-3-((2-(1H-PYRROL-1-YL)PHENYL)IMINO)INDOLIN-2-ONE

Abstract

The coordination chemistry of (E)-3-((2-(1H-pyrrol-1-yl)phenyl)imino)indolin-2-one(L1) and (E)-3-((2-(1Hbenzo[ d]imidazol-2-yl)phenyl)imino)indolin-2-one(L2) has been investigated with the Cu(II), Co(II)and Ni(II)ions. The donor atoms and the plausible geometry of the complexes were examined by means of elemental analyses, molar conductance, magnetic moment, UV- Vis, IR, Far-IR and ESR spectra. The IR spectra results display the binding mode of the ligand involving azomethine nitrogen and carbonyl oxygen atoms. The electronic spectral and magnetic moment results indicate that Co(II) and Ni(II) complexes have octahedral geometry, while Cu(II) complex is distorted octahedral. The in-vitro biological screening effects of the investigated compounds were tested against bacterial species (Bacillus subtilis, Salmonella typhi) and fungal strains (Aspergillus niger, Candida albicans) by disc diffusion method. A comparative study of inhibition values result show that the metal complexes were found to be more active than the ligand. In addition, DNA cleavage studies for the newly prepared compounds were also studied. These studies indicate that the DNA cleavage efficacy increased in the complexes relative to the parental ligand.