SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTITUBERCULAR AND ANTIMICROBIAL ACTIVITY OF Cu(II) AND Zn(II) COMPLEXES WITH TRIDENTATE LIGAND

Abstract

Cu(II) and Zn(II) complexes were prepared with ethyl 2-{[(E)-(2-hydroxynaphthalen-1-yl)methylidene]amino}-4,5,6,7- tetrahydro-1-benzothiophene-3-carboxylate(HETBT-Np),a tridentate Schiff base ligand. Schiff base ligand was subjected to various spectroscopic investigations like NMR, IR, UV-Visible, and LCMS for structural determination, while complex geometry was proposed on the basis of FTIR, UV-Visible, ESR, XRD, TGA spectroscopy and measurement of molar conductivity, magnetic susceptibility, and elemental analysis. All the prepared compounds displayed in vitro antimicrobial activity against Drug Resistant Extended Spectrum β-Lactamase (ESBL), and Metallo β-lactamase (MBL) producing uropathogens and antitubercular activity against Mycobacterium tuberculosis (H37Rv strain). Metal complexes exhibited enhanced biological activity compared to parent Schiff base. Among the studied metal complexes, Cu (II) complex surfaced as the most active compound against all of the tested microbial strains.