FORMULATION AND DEVELOPMENT OF LIPID BASED NON-AQUEOUS NANO EMULSION FOR SELECTED NSAID

Abstract

Oral administration of non-steroidal anti-inflammatory drugs is avoided in patients with disease like peptic ulcer, gastro esophageal reflux (GERD), irritable bowel syndrome. Administration of drug through topical route through the skin could reduce the above side effects associated with oral administered drug formulation. Hence, the aim of present study was to develop Nonaqueous Nanoemulsion (NANEs) of Naproxen for topical administration. NANEs is a multiphase colloidal dispersion heterogeneous system consist of fine nonaqueous polar solvent in oil dispersion with surfactant. NANEs of naproxen were prepared using high energy emulsification method, which break large micro droplets into nano size droplets. Drug-excipients Compatibility was studied by FT-IR. Rheology, Flow behavior, Viscosity, pH, Globule size, Drug content, in-vitro drug release of NANE were performed. For optimization of nonaqueous nanoemulsion Box- Behnken experimental design was implemented. The variables selected are phase volume ratio, surfactant concentration and stirring time. Data analysis showed that surfactant concentration and phase volume ratio significantly affect the viscosity of the formulation. From the present study, it can be concluded that a stable non-aqueous nanoemulsion can be obtained by using glycerin as dispersed phase, mineral oil as continuous phase and glycerol monostearate as surfactant, which can be used as vehicle for the water sensitive materials. This nonaqueous nanoemulsion has improved the stability of Naproxen and overcome the oral drawback associated with it.