ANTITUMOR ACTIVITY OF METHANOLIC EXTRACT OF CYNODON DACTYLON LEAVES AGAINST EHRLICH ASCITES INDUCED CARCINOMA IN MICE

Abstract

The aim of the present study is to evaluate the effect of methanolic extract of leaves of Cynodon dactylon against Ehrlich ascitic Lymphoma (ELA) in Swiss albino mice. The tumor was induced in mice by intraperitoneal injection of EAC (1X106cells/mouse). Methanolic extract of cynodon dactylon was administered to the experimental animals at a dose of 80μg/kg/day after 24 h of tumor inoculation. The antitumor effect of extract was evaluated by assessing in vitro cytotoxicity, hematological parameters and liver enzymes. The methanolic extract brought back the altered levels of the hematological parameters and liver enzymes. Thus the present study revealed that methanolic extract of Cynodon dactylon possessed significant antitumor activity and hepatoprotective effect.